One of GM's most durable automatic gearboxes, the 4L80E transmission is designed to manage significant torque and horsepower. It is based on the renowned TH400 and is ideal for heavy-duty vehicles and high-performance builds due to its electronic controls, robust gearbox, and increased efficiency.

The 4L80E transmission is developed for cars with diesel or big-block engines and provides exceptional durability under heavy loads. For enthusiasts seeking improved power handling and drivability over the 4L60E or TH400, it's the preferred option due to its smooth shifts, dependable overdrive, and capacity to manage up to 450–500 lb-ft of torque.